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Proton Pump Inhibitors (PPIs) are a group of drugs that work to reduce gastric acid production. The stomach contains a pump that produces gastric acid; PPIs bind this pump and prevent acid from being pumped into the stomach. Medications such as Prilosec, Prevacid, Nexium and Aciphex are prescribed to patients with gastroesophageal reflux disease (GERD), dyspepsia, ulcers, Zollinger-Ellison Syndrome and sometimes stomach infections.

Although most side effects of Proton Pump inhibitors are minor, PPIs have recently been linked to an increased risk of bone fractures. In particular, those who have been on a PPI for 5 or more consecutive years are at a greater risk of hip fracture. Those who have been on a PPI for 7 plus years are at greater risk of fractures in general and osteoporosis.

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